Although neuronal protein aggregation occurs during healthy ageing, excessive accumulation is a hallmark of neurodegenerative pathology, including Lewy bodies in idiopathic PD, neurofibrillary τ tangles and amyloid plaques in AD, polyglutamine aggregates in Huntington’s disease [59,194] and ubiquitin/p62 positive inclusions in ALS. This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.