Additionally, the manifestation of static encephalopathy of childhood with neurodegeneration in adulthood (SENDA) is associated with human mutations in WDR45. SENDA is a variant of NBIA reported by Kruer and colleagues in 2012 [82], with affected individuals exhibiting childhood intellectual impairments and severe dystonia-Parkinsonism in adulthood. This evidence concerns the gene WDR45 and neurodegeneration with brain iron accumulation.