As (S)-Lacosamide has recently been shown to specifically inhibit CRMP2 phosphorylation via cyclin-dependent kinase 5 (Cdk5) [16], we hypothesized that treatment with (S)-Lacosamide would prove to be therapeutic in models of CLN6-Batten disease [16]. This evidence concerns the gene DPYSL2 and juvenile neuronal ceroid lipofuscinosis.