GLP-1R agonists used in T2D treatment are either derivatives of native GLP-1 (liraglutide, albiglutide, semaglutide and dulaglutide), which have been modified to be resistant to DPP-4 inactivation, or derivatives of exendin-4 (exenatide, lixisenatide and exenatide-LR)4,17. The gene discussed is GCG; the disease is type 2 diabetes mellitus.