In cardiomyocyte HL-1 cells infected with CVB3, miR-126 facilitated viral replication by suppressing sprouty-related, EVH1 domain containing 1 (SPRED1), low-density lipoprotein receptor-related protein 6 (LRP6), and Wnt-responsive Cdc42 homolog 1 (WRCH1), inhibitory factors to the viral cytopathogenicity (138), and miR-590-5p facilitated prolonged viral replication by suppressing antiviral sprouty-1 (Spry1), moreover, cells over-expressing miR-590-5p were more susceptible to infection (139). The gene discussed is RHOU; the disease is infection.