Our recent study in dogs with COPD and chronic bronchitis indicate that infection by PA and Bordetella bronchiseptica, and by viral-bacterial combination activate the antagonistic STAT6 and EGFR signaling to inhibit FOXA2, resulting in goblet cell hyperplasia and metaplasia and mucus hypersecretion (16). The gene discussed is EGFR; the disease is chronic obstructive pulmonary disease.