We therefore analyzed the role of these cells in modulating cytokine secretion from T cells during infection with Salmonella. Ex vivo depletion of CD11b+Gr1+ cells from splenocytes obtained from Salmonella—infected mice resulted in considerable recovery in the ability of splenic T cells to secrete IL-2 upon stimulation through the TCR (Figure 2D). The gene discussed is ITGAM; the disease is infection.