SOD1 and amyotrophic lateral sclerosis: Since the identification in 1993 (Rosen et al., 1993) of copper/zinc superoxide dismutase 1 (SOD1) in ALS patients with an autosomal dominant trait in 1993 (Aoki et al., 1993), more than 25 genes have been reported as causative genes of familial ALS (Maday et al., 2014; De Vos and Hafezparast, 2017; Ghasemi and Brown, 2018; Cook and Petrucelli, 2019).