Although substantial differences have been reported in SOD1-ALS compared with FUS-ALS and TARDBP-ALS (Fujimori, 2018), SOD1-, TARDBP-, and FUS-mutant MNs have common features, suggesting a role for AP-1 in the neurodegeneration observed in ALS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.