In Peng Head-Neck statistics18, GBP1 over-expression was found in oral cavity squamous cell carcinoma tissues compared with normal tissues with a fold change of 7.854 (P = 4.15E-24), while Talbot19 observed 2.962-fold increase in GBP1 mRNA expression in tongue samples (P = 3.10E-12), Ginos20 found 5.397- fold increase in GBP1 mRNA expression in HNSCC tissues (P = 2.70E-13), Estilo21 found 4.286- fold increase in GBP1 mRNA expression in tongue tissues (P = 3.51E-9) and Ye22 found 4.450- fold increase in GBP1 mRNA expression in tongue tissues (P = 5.39E-5, Table 1). The gene discussed is GBP1; the disease is head and neck squamous cell carcinoma.