In univariate analysis, we found that tumor stage (HR = 1.80, 95% CI: 1.23–2.66, P < 0.05), T-stage (HR = 1.36, 95% CI: 1.05–1.76, P < 0.05), N-stage (HR = 1.36, 95% CI: 1.10–1.68, P < 0.05), high expressions of GBP1/6/7 were linked to shorter OS of HNSCC patients. The gene discussed is GBP1; the disease is neoplasm.