TNFRSF1A and systemic inflammatory response syndrome: Interestingly, the S166A mutation did not only inhibit TNF-mediated inflammation in the Sharpincpdm/cpdm, NEMOIEC-KO and TNF-induced SIRS mouse models, but also fully prevented liver pathology in NEMOLPC-KO mice, which develops independently of TNFR1, Fas and TRAILR49.