SNCA and Parkinson disease: Our study demonstrated that Tubastatin A treatment protected dopaminergic neurons within the substantia nigra of rats through the reduction of alpha-synuclein expression, up-regulation of key members of the chaperone-mediated autophagy, reduction of neuroinflammation, increase of protein acetylation, modulation of phosphorylation of alpha-synuclein, and rescue of PD-related pathological pathways.