SNCA and Parkinson disease: Recent studies addressing the role of the ubiquitin-proteasome system in a mouse model of PD suggest that HDAC6 could mediate the dissociation of Hsp90-containing heat shock factor 1 (Hsf1) complex, and protect dopaminergic neurons from cytotoxic alpha-synuclein aggregates by stimulating the formation of aggresome-like inclusions14.