Using in vitro and in vivo preclinical models, we previously found that, in addition to its canonical antiapoptotic role, bcl-2 modulation in human melanoma cells regulates tumor progression-associated properties and tumor metastatization through a BH4 domain-dependent mechanism.4–6 Recently, we also described that bcl-2-mediated modulation of microRNA-211 regulates melanoma cells migration and the activity of microphthalmia-associated transcription factor.7 The gene discussed is MITF; the disease is neoplasm.