These findings indicate that the impairment of NF-κB pathway in bcl-2 overexpressing melanoma cells interferes with the bcl-2 ability to induce IL-1β, CCL2, IL-17 and its upstream regulators RORa and RORc, thus resulting in the failure of bcl-2-mediated macrophage reprogramming. Here, NFKB1 is linked to melanoma.