As compared with H1299 control cells and similar to melanoma cells, CM from H1299 cells overexpressing bcl-2 promoted M2 polarization of M-DM, associated with increased expression of M2 (CD206, IL-10 and CCL1) and reduction of M1 (COX-2 and IL-12) markers (online supplementary figure S3A) and increased THP-1 cell migration (online supplementary figure S3B). This evidence concerns the gene MRC1 and melanoma.