Of note, an increased expression of IL-17 (IL-17RA), IL-8 (CXCR1) and CCL2 (CCR2) receptors was also observed on M-DM exposed to CM from bcl-2 overexpressing clone (online supplementary figure S2E), suggesting a larger impact of cancer cell-specific bcl-2 on the interplay between the tumor and the stromal compartment. The gene discussed is CXCL8; the disease is cancer.