HLA-C and viral infectious disease: Multiple factors are responsible for the selection and dominance of epitope-specific T cells and associated responses during acute viral infections, including (i) precursor frequency (36), (ii) strength and stability of peptide MHC binding to its cognate T cell receptor (TCR) (37), (iii) expression of the antigen (38, 39), (iv) the extent and manner in which these antigens are processed and presented (40), and (v) the contribution of amino acids flanking the anchoring residues (41).