The intravitreal administration of a transgene vector of AAV5 carrying pigment epithelium derived factor (PEDF) (AdGVPEDF.11D) in three murine models of choroidal neovascularization (CNV) significantly inhibited neovascularisation.62 This study led to one of the first gene therapy trials for nAMD (NCT00109499), a phase I, dose-escalation intravitreal delivery of AdPEDF.11. The gene discussed is SERPINF1; the disease is choroidal neovascularization.