Mahmoud et al. clearly showed that physiological doses of genistein (0.5–10 μM) significantly reduced the methylation levels of estrogen receptor (ER)-β promoter, resulting in increases in ER-β expression and induction of ER-β transcriptional activity in human PCa LNCaP and LAPC-4 cells. The gene discussed is ESR2; the disease is posterior cortical atrophy.