IGHE and infection: Therefore, the present study aimed to: (i) assess the capacity of zoonotic parasites (Toxocara canis, Ascaris suum, Schistosoma mansoni, Toxoplasma gondii) and parasitic fungi (Aspergillus fumigatus) to cause α-Gal sensitization following the production of glycotope-specific IgE Abs in infected individuals; (ii) to investigate the possible correlation between immune responses to α-Gal and human infections caused by these pathogenic agents.