CD8A and non-small cell lung carcinoma: At 10 weeks of age, a significant increase in CD3+, CD8+ T cells, and in type-1 polarized macrophages was observed in the lungs of K-RasG12D mice, as compared to wt mice (Figure 1e, upper panels), suggesting that a spontaneous antitumor immune response was present in the early stages of NSCLC development.