TNKS and cancer: Other structurally different inhibitors have also been reported to impair WNT signaling in vitro by targeting tankyrase, including IWR-1/2 [28], JW74/55 [17,29], WIKI4 [30], G007-LK [31], with some validated for anti-tumor efficacy in xenograft and/or genetically engineered mouse models of cancer [32].