PCOS theca cells also have increased levels of a variant DENND1A transcript, termed hDENND1A.V2, an alternatively spliced mRNA that encodes a truncated protein (hDENND1A.V2), which has a unique 33 amino acid C-terminus encoded by exon 20A that distinguishes it from the longer transcript encoding DENND1A.V1 [15]. This evidence concerns the gene DENND1A and polycystic ovary syndrome.