ADCY1 and neoplasm: As shown in Figure S1, studies in mouse Leydig MA-10 tumor cells infected with hDENND1A.V2 adenovirus as compared to a Null (empty vector) adenovirus, demonstrated that forced expression of hDENND1A.V2 augments steroid production (17α-hydroxyprogesterone (17OHP4) and progesterone (P4), particularly in response to forskolin stimulation, which mimics the action of luteinizing hormone (LH) through activation of adenylate cyclase (Figure S1).