Virus-negative MCC was significantly associated (p = 0.02) with an increased N:CD8 ratio (15.93 × 10−3; 95 % CI: 2.20 × 10−3–115.16 × 10−3), compared with virus-positive MCC (0.81 × 10−3; 95% CI: 0.16 × 10−3–4.12 × 10−3). The gene discussed is CD8A; the disease is Merkel cell skin cancer.