CD44 and ovarian carcinoma: Later, it was found that another plant-derived compound, celastrol, strongly suppresses PIN1 expression in ovarian cancer cells and this is accompanied by downregulation of the expression of CD44, NANOG, KLF4, and OCT4 as well as a decrease in the CD44 high/CD24 low cell population (i.e., CSC-like cells) [200].