A recent study of Song et al. established a crucial role of HSP90A (HSPC1; [41]) in the stemness development in immune-refractory tumors: The NANOG-driven HSP90A/TCL1A/Akt pathway is responsible for the emergence of CSC-like tumor cells exhibiting an insusceptibility to immune attack, aggressiveness, and multi-modal resistance [27]. The gene discussed is AKT1; the disease is neoplasm.