The importance of GRP78’s interaction with LOXL2 (lysyl oxidase-like 2) was established for EMT induction in breast cancer cells [220]; this interaction results in stimulation of the IRE1/XBP1 signaling pathway followed by expression of SNAI1, SNAI2, ZEB2, and TCF3 being the EMT drivers. This evidence concerns the gene HSPA5 and breast cancer.