HSP90AB1 and triple-negative breast carcinoma: In a more recent publication dedicated to triple-negative breast cancer [81], the inhibitor (L80)-sensitive HSP90 chaperone function was shown to be necessary for activation of the Akt/MEK/ERK/JAK2/STAT3 signaling network, which generated CSC-like cell phenotypes (CD44+/CD24− cells with high ALDH1 activity, which are able to form mammospheres).