In particular, the binding of nestin with cyclin D1 and heat shock cognate protein HSC71 (HSPA8 [41], a non-inducible form of the cytosolic HSP70 chaperone) and also nestin-dependent phosphorylation of HSC71 along with the fact that nestin and HSC71 reciprocally regulate expression levels of each other were revealed in glioblastoma cells [120]. The gene discussed is HSPA8; the disease is glioblastoma.