MMP9 and cancer: In another model with HSP70-2 (HSPA1B [41]) gene silencing in human ovarian cancer cells, HSP70-2 knockdown upregulated the epithelial markers E-cadherin and cytokeratin, whereas it downregulated a set of EMT- and cancer stemness-associated proteins, including N-cadherin, vimentin, Snail, Slug, Twist, MMP2, MMP9, and others [118].