Another plant-derived compound, isoliquiritigenin (a chalcone-type bioflavonoid), was shown to suppress both the self-renewal ability and the expression of cancer stemness markers, such as CD44 and ALDH1, in CSCs from oral squamous cell carcinoma; in addition, the invasive and metastatic capacities became impaired in isoliquiritigenin-treated oral CSCs [233]. The gene discussed is ALDH1A1; the disease is oral cavity squamous cell carcinoma.