Those exosomes can contain TGF-β2, TNF1α, IL6, Akt (protein kinase B), β-catenin, matrix metalloproteinases (MMPs), microRNAs, and other EMT-inducing factors that influence tumor cell phenotypes and upregulate stemness-associated properties, such as motility, extracellular proteinase activity, invasiveness, and spheroid formation [19]. This evidence concerns the gene IL6 and neoplasm.