Interestingly, antisense long noncoding RNAs (lncRNAs) may also affect HSP27 phosphorylation/dephosphorylation, as BX357664 was found to downregulate the EMT-driving TGFβ1/p38/HSP27 pathway in renal cell carcinoma [144]. This evidence concerns the gene HSPB1 and hereditary clear cell renal cell carcinoma.