With the use of RNA interference (RNAi)-based silencing, it was shown that GRP94 is conducive to the aggressiveness of gliomas by activating such cancer stemness-associated properties as cell migration and invasion [209]; mechanistically, it was due to GRP94-mediated stimulation of the Wnt/β-catenin signaling pathway, one of the pivotal pathways in CSC phenotype formation. The gene discussed is HSP90B1; the disease is cancer.