Contrary to all those publications [214,215,216,217,218,219,220,221,222,223,224], there are at least three research papers dedicated to hepatocellular carcinoma cells [225,226,227] in which EMT and cancer stemness were associated with downregulation of intracellular GRP78, which seems rather unexpected and hard to explain. The gene discussed is HSPA5; the disease is hepatocellular carcinoma.