CALR and pancreatic neoplasm: In the same study, calreticulin was found to be co-localized with pEGFR1173, fibronectin, and integrin β1, while being co-immunoprecipitated with fibronectin, integrin β1, and c-Myc, which suggests the direct involvement of calreticulin in the regulation of EGF-induced EMT in pancreatic tumors [277].