FZD4 and colorectal cancer: Other researchers have demonstrated that AGR3 is also implicated in stemness development/maintenance in colorectal cancer via AGR3-mediated modulating of the Wnt/β-catenin signaling pathway; notably, these stemness-promoting and Wnt/β-catenin pathway-modulating activities of AGR3 were dependent on the presence of frizzled 4 (FZD4), a G-protein-coupled receptor for Wnt proteins [270].