Similarly, the elevated expression of GRP75 in intrahepatic cholangiocarcinoma cells was associated with EMT induction, which was accompanied by a decrease of the E-cadherin level while increasing the expression of vimentin and Snail; the suppression of GRP75 expression resulted in reverse effects, namely the accumulation of E-cadherin and downregulation of vimentin and Snail expression [253]. The gene discussed is VIM; the disease is intrahepatic cholangiocarcinoma.