HSPA5 and oral cavity squamous cell carcinoma: Later, GRP78-downregulating treatments with isoliquiritigenin enabled Hu et al. [233] to discover the essential role of GRP78 in the expression of CD44, ALDH1, and ABCG2 (all are stemness markers) and the ability for invasion and metastatic spread and resistance to chemotherapy in CSCs from oral squamous cell carcinomas.