Isoliquiritigenin (a bioflavonoid), inhibiting the total GRP78 expression in oral cancer CSCs, also reduced the membrane GRP78 level, which was accompanied by downregulation of the expression of LDH1, CD44, and ABCG2, as well as an impairment of invasion and metastatic growth [233]. Here, HSPA5 is linked to lip and oral cavity carcinoma.