Taking into consideration that (i) cell migration and spheroid formation, (ii) resistance to drugs and ROS, and (iii) adaptiveness to hypoxia and energy starvation are hallmarks of CSCs (see the introduction section), the described activities of TRAP1 in glioblastomas characterize this mitochondrial chaperone as a one of the drivers in cancer stemness development. The gene discussed is TRAP1; the disease is cancer.