PTPRC and pulmonary fibrosis: Similarly, when mice with bleomycin-induced pulmonary fibrosis were orally treated every day with the anti-fibrotic agent pirfenidone (300 mg/Kg/day) for two weeks starting 10 days after bleomycin treatment, the fibrocyte (CD45+ Collagen I+) numbers in the lung dropped significantly on day 14 (p = 0.0097); this drop was mirrored by a fall in collagen content on day 28 (p = 0.0012) [99].