In colorectal HCT116 cells, sorcin activates EMT through activation of the PI3K/Akt/mTOR pathway [58]; in breast cancer, sorcin silencing inhibits metastatization and EMT, by increasing the expression of E-cadherin and decreasing that of vascular endothelial growth factor (VEGF) [67]. This evidence concerns the gene AKT1 and breast cancer.