It also showed downregulation of the putative tumor-suppressor SFRP1 and other genes involved in metabolic pathways (SLC25A10) and upregulation of the cytokine IL1B, the protein involved in the contractile system of striated and smooth muscles TPM1, and other genes with uncertain roles in cancer (SHROOM2 and RHOB). The gene discussed is IL1B; the disease is cancer.