F9 and hemophilia B: In essence, both antisense strategies lead to a rescue of F9 mRNA expression and an increase in coagulation activity, which may be able to revert the phenotype into a mild or subclinical hemophilia B. Interestingly, the RNA duplex formation and association with U7snRNP did not hamper translation in the cytosol, which suggests detachment of the complex at the nuclear pore or during the pioneer round of translation.