A subset of inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-12p70, IL-21, IL-23, MPO, sICAM, sVCAM, CRP) and chemokines (MIP-1α, MIP-1β, ITAC, MIP-3α, MIP-3β, and 6CKINE) was significantly elevated in SCD compared to controls (Table B in S1 File). This evidence concerns the gene IL21 and Schnyder corneal dystrophy.