In conclusion, our experiments have suggested that lncRNA NORAD attenuates endothelial cell senescence, endothelial cell apoptosis, and atherosclerosis via NF-κB and p53–p21 signaling pathways and IL-8, in which NORAD-mediated effect on IL-8 might through the direct interaction with its transcription repressor SFPQ. Here, CXCL8 is linked to atherosclerosis.