Even though its exact function in lysosomal physiology still needs to be clarified the available experimental evidence shows that aberrant processing of autophagosomes as well as an increased lysosomal pH under conditions of starvation is the prominent phenotype of TMEM175-loss (Cang et al., 2015; Jinn et al., 2017) and likely connects this lysosomal pathology to PD. The gene discussed is TMEM175; the disease is Parkinson disease.