The objectives of this study are 1) to determine whether there is a need to adjust PZC for inflammation to estimate the prevalence of nutritional zinc deficiency in preschool children (PSC) and nonpregnant women of reproductive age (WRA); and, if adjustment is warranted, 2) to determine whether it is necessary to adjust PZC for CRP, AGP, or both; and 3) to compare the different adjustment approaches for correcting for inflammation and estimating the prevalence of zinc deficiency. The gene discussed is CRP; the disease is Zinc deficiency.