ZEB1 and cancer: ZEB1 is a core EMT-TF of the ZEB family and is implicated in cellular plasticity, dissemination, and a dormant-to-proliferative phenotypic switch at the distant site as well as being a determinant of worse clinical prognosis in most human cancers (Zhang et al., 2015; Katsura et al., 2017; Krebs et al., 2017).