Similarly, reconstitution of miR-875-5p, whose expression is strongly down-regulated in prostate cancer clinical samples, led to enhanced radiation response in PCa cell lines and xenografts by disabling EGFR nuclear translocation and upstream signaling of ZEB1-triggered activation of CHK1 and DNA repair machinery (El Bezawy et al., 2017). Here, ZEB1 is linked to Familial prostate cancer.