Strikingly, ZEB1 also governs the inflammatory phenotype in breast cancer cells by regulating the secretion of pro-inflammatory cytokines IL-6 and IL-8 and induction of fibroblasts and growth of myeloid-derived suppressor cells, indicating its key role in the tumor microenvironment and formation of the pre-metastatic niche (Katsura et al., 2017; Carpenter et al., 2018). Here, ZEB1 is linked to breast carcinoma.