The latest study found that CpG-ODN activates TLR9/MyD88 signaling and induces the production of glycosylated IgA1 and IgG-IgA ICs through the IL-6 and/or a proliferation-inducing ligand (APRIL) pathway, and further aggravates kidney damage. The gene discussed is TNFSF13; the disease is Nephropathy.