We analyzed CD19+ B cells, CD19+CD5+ B1 cells, and CD19+CD5– B2 cells with the clinical data and found that SCr (r = −0.110, P = 0.032), BUN (r = −0.113, P = 0.028), and CKD (r = −0.318, P < 0.001) were negatively correlated with B1 cells. Here, CD19 is linked to chronic kidney disease.