TGFB1 and type 2 diabetes mellitus: Neutralizing all three mammalian TGF-β isoforms (-β1, -β2, and -β3) with antibodies reduced ECM gene (fibronectin and type IV collagen) expression and attenuated renal fibrosis in mice with type 1 or type 2 diabetes (Sharma et al., 1996; Ziyadeh et al., 2000).