Therefore, A group of associated atherosclerosis genes was regulated, endothelin 1 (EDN1), angiotensin II (ANGII), as well as thromboxane A2 (TxA2) downregulated and endothelial nitric oxide synthase (eNOS), prostacyclin (PGI2), and VEGF upregulated (Wang et al., 2017). This evidence concerns the gene EDN1 and atherosclerosis.