PIN1 and hepatocellular carcinoma: Pin1 binds to the ERK-mediated phosphorylated XPO5 in hepatocellular carcinoma (HCC) and changes XPO5’s conformation through cis-trans isomerization, leading to the retention of XPO5 in the nucleus and the impaired nuclear export of pre-miRNAs (Li J. et al., 2018).