In most cases, it is characterized by translocation (15;17) with the PML-RARA fusion gene (1–3), but about 1–2% of APL cases are due to rare variant translocations including ZBTB16/RARA, NMP/RARA, NUMA/RARA, STAT5B/RARA, PRKAR1a/RARA, BCOR/RARA, and FIP1L1/RARA (4–6). The gene discussed is RARA; the disease is acute promyelocytic leukemia.