Adaptive NK cells in HCMV infection are characterized by downregulation of receptors such as NKp30 and NKp46 (Guma et al., 2004), downregulation of the transcription factors PLZF and IKZF2 and loss of intracellular adaptor signaling molecules (Lee et al., 2015; Schlums et al., 2015). The gene discussed is NCR3; the disease is cytomegalovirus infection.