IL18 and irritable bowel syndrome: We also found an enrichment of the Firmicutes, Proteobacteria, and Actinobacteria phyla, where enterobacteria, enterococcus, Akkermancia, Alteromonas, and others play important roles in the pathophysiology of polygenic IBS patients, associated with SNPs in TLRs, IL18, IL23, and IL17, which can acts as a pro or anti-inflammatory effect depending on environment.