CXCL8 and neoplasm: Notably, another signaling role of the environmental lactate has been investigated in endothelium as lactate could be up-taken by endothelial cells through the MCT-1, thus stimulating the autocrine NF-κB/IL-8 (CXCL8) pathway which affects tumor angiogenesis in terms of endothelial migration, vessels permeability and morphology (58).