Treatment of syngeneic mice bearing 4T1 TNBC tumors with G47Δ-mIL12 lead to a CD8+ T cell-dependent inhibition of 4T1 tumor growth, inhibition of tumor angiogenesis, and prevention of lung metastasis, suggesting local and systemic anti-cancer effects of G47Δ-mIL12. This evidence concerns the gene CD8A and cancer.