It is important to note that IL-12 in G47Δ-mIL12 virus may have played a critical role in activating APCs, since IL-12 is a potent MDSC modulator and shifts splenic MDSCs (isolated from 4T1-tumor bearing BALB/c mice) into CD11c+CD86+ activated DCs (17). This evidence concerns the gene CD86 and neoplasm.