CD8A and neoplasm: In vivo, G47Δ-mIL12 treatment effectively inhibited 4T1 tumor growth, both primary and contralateral, and prevented metastasis to the lungs, which were associated with an enhanced APC activation, increased intratumoral CD8+ T-cell infiltration with subsequent reduction in myeloid-derived suppressor cells (MDSCs), and inhibition of angiogenesis.