G47Δ-mIL12 (14) is a genetically engineered OHSV that has similar genetic modifications to T-VEC (15, 16) but contains an extra safety feature [i.e., ICP6 inactivation that restricts OHSV replication to cancer cells (16)] and expresses murine Interleukin 12 (IL-12) (instead of GM-CSF). Here, CSF2 is linked to cancer.