RTN4R (reticulon 4 receptor), which is an essential role in axonal regeneration and structural plasticity in the central nervous system (19, 20), has been elucidated to be associated with the risk for sporadic amyotrophic lateral sclerosis (21, 22) and schizophrenia (23, 24). This evidence concerns the gene RTN4R and sporadic amyotrophic lateral sclerosis.