AKT1 and pancreatic intraductal papillary-mucinous neoplasm: As shown in Figure 7B, IPMN and PanIN did not differ greatly in terms of sensitivity on gemcitabine; although PanIN had a more rapid proliferation speed in normal culture condition (Figure S6A), gemcitabine inhibitory effect seemed nearly equal when calculated proportionally, indicating a rigorous Akt inhibitory resistance in PanIN alone.