The same scenario happened in CD24/44 stem cell system in PanIN/IPMN (Figures S7B, S7C) (31), which was reported as pancreatic cancer stem cell (CSC) markers, CD24/CD44 population decreased significantly in IPMN than in PanIN when treated with Akti. Here, CD44 is linked to pancreatic intraductal papillary-mucinous neoplasm.