Mixed cohort (n = 65):– SK1 mRNA level is higher in breast cancer tissue compared to adjacent normal breast tissue– Basal-like subtype displays the highest SK1 gene expression– SK1 expression is higher in triple negative breast cancer patients– High expression of SK1 is correlated with poorer survival and prognosis– HER2-, estrogen-, and progesterone-negative tumors expressed higher SK1 mRNA. Here, SPHK1 is linked to breast cancer.