Similarly, if a lesion is seen on imaging, such as screening mammography, a core needle biopsy will be taken to provide a diagnosis (9), and if indicative of breast cancer, tissue is sent for further examination to determine hormone (estrogen and progesterone) receptor and human epidermal growth factor (HER2) status, as this will influence treatment decisions and provide information regarding prognosis (10). The gene discussed is ERBB2; the disease is breast carcinoma.