Interestingly, a recent study showed that intracellular accumulation of tau proteins could in turn aggravate autophagy deficits by disrupting IST1-regulated ESCRT-III complex formation and autophagosome-autolysosome fusion, which formed a vicious cycle between tau accumulation and autophagy deficit in AD and the related tauopathie [13]. This evidence concerns the gene MAPT and tauopathy.