AKR1C2 and cancer: Out of these five proteins, DCP1A regulates Atg12 and is linked to autophagy and proteasome degradation pathways [40], TMSB4X regulates TGFβ1 and participates in the progression of cancer [41], MGST3 increases in the LT97 adenoma cells and participates in cancer development [42], AKR1C2 is a key enzyme in the process of progesterone metabolism and is closely related to gynecological tumor development [43], and ERLIN1 is influences the survival time of pancreatic cancer patients [44].