Among the 38 genes, HSD17B4, ACAA1, and PXMP4 were highlighted for their down-regulation both at mRNA level and protein level, their prognostic effects, their correlations with immune infiltrations, immunomodulator gene expressions, the proliferation marker (MKI67) expression and/or anti-cancer drug sensitivities in NSCLC. The gene discussed is MKI67; the disease is cancer.