Through correlation analyses (Supplementary Table S6), ACAA1 expression was shown to be negatively correlated with the IC50 values of five anti-cancer drugs including AZD0530 (r = −0.261, p = 0.014), AZD6244 (r = −0.281, p = 0.008), Erlotinib (r = −0.211, p = 0.047), Lapatinib (r = −0.234, p = 0.028), and ZD-6474 (r = −0.285, p = 0.007) while no significant correlation was shown for HSD17B4 or PXMP4 expression with the IC50 values of all the 24 drugs (p > 0.05). The gene discussed is HSD17B4; the disease is cancer.