Notably, considering the importance of HSD17B4 and ACAA1 in peroxisomal β-oxidation of very long fatty acids, the dysfunction of the process in NSCLC was indicated, consistent with the anti-tumor function of β-oxidation in lung cancer in a previous study (Srivastava et al., 2014). This evidence concerns the gene ACAA1 and non-small cell lung carcinoma.