In addition, among the top 10 correlations (with the lowest p-values) (Supplementary Table S5), all the 10 correlation in LUSC and 7 of 10 correlations in LUAD were associated with HSD17B4 and all the correlations were positive ones, indicating although all the three genes were associated immune response, the immunoregulatory potential of HSD17B4 in NSCLC was highlighted. This evidence concerns the gene HSD17B4 and non-small cell lung carcinoma.