CCNB1 and esophageal squamous cell carcinoma: In a related study, inhibition of UBE2C, an upregulated marker of esophageal squamous cell carcinoma, inhibited the growth of esophageal squamous cell carcinoma by modulating the expression of CCNB1, which was one of the ten hub genes identified in our previous study (Palumbo et al., 2016).