In addition, a recent study (187) using bone marrow biopsies from 35 myeloma patients revealed a significant correlation of versikine accumulation with infiltration of CD8+ T cells supporting a model in which macrophages and regulatory DCs secrete tolerogenic versican which is subsequently degraded, generating versikine and further altering the immunosuppressive nature of the tumor microenvironment. Here, CD8A is linked to neoplasm.