HAVCR2 and neoplasm: These include CD44, which alters T cell migration (42, 43), FAS ligand (FASL), which in a soluble form acts as a decoy receptor to reduce activation induced apoptosis (44), and persistent Lymphocyte Activating 3 (LAG3) or T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), which are markers of T cell exhaustion in tumor-infiltrating lymphocytes (45).