Consistent with our previous findings (23, 25), HDI also reduced autoantibody production and autoimmunity in lupus-prone mice, as reflected by reduced skin lesion, anti-nuclear antibody (ANA), and anti-dsDNA IgG2a titers in MRL/Faslpr/lpr mice treated with HDIs for 4 weeks (Figures 2A–C). This evidence concerns the gene BTG3 and systemic lupus erythematosus.