It was also reported that the population of CD8+, CD45RO+, PD-1+, TBET+, EOMES+ T cells increased after treatment only in TILs if compared to the peripheral blood (136), and that the gene expression signature of EOMES+, CD69+, CD45RO+ T cells was associated with greater tumor shrinkage in both therapies (142). Here, PDCD1 is linked to neoplasm.