TAM-like macrophages in HCC highly express two genes, SLC40A1 and GPNMB. The former encodes ferroportin, a transporter exporting iron from cells, and regulates pro-inflammatory cytokines, like IL-6, IL-23, and IL-1β, through a Toll like receptor (TLR)-dependent pathway (131). The gene discussed is SLC40A1; the disease is hepatocellular carcinoma.